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Recent Publications

See complete list on PubMed

Identifying Antigenic Switching by Clonal Cell Barcoding and Nanopore Sequencing in Trypanosoma brucei

Touray, A, Sternlieb, T, Isebe, TI and Cestari, I 

Bio-protocol. Vol 13, Iss 24, Dec 20, 2023. doi: 10.21769/BioProtoc.4904

High-Efficiency Transformation and Expression of Genomic Libraries in Yeast

Loock M, Antunes LB, Heslop RT, De Lauri AA, Brito Lira A, Cestari I.

Methods Protoc. 2023 Sep 21;6(5):89. doi: 10.3390/mps6050089.

Preprint available @ bioRxiv 2023.08.07.552314; doi: https://doi.org/10.1101/2023.08.07.552314

PI(3,4,5)P3 allosteric regulation of repressor activator protein 1 controls antigenic variation in trypanosomes

Touray AO, Rajesh R, Isebe T, Sternlieb T, Loock M, Kutova O, Cestari I

eLife 2023, eLife12:RP89331 doi: https://doi.org/10.7554/eLife.89331.4

Preprint available @ bioRxiv 2023.05.11.540368; doi: https://doi.org/10.1101/2023.05.11.540368

Genome-wide libraries for protozoan pathogens drug target screening using yeast surface display
Heslop R, Gao M, Brito-Lira A, Sternlieb T, Loock M, Sanghi SR, Cestari I
ACS Infect. Dis. 2023, 9, 5, 1078-1091 (Selected Issue Cover Page)
Preprint available @ bioRxiv, 2022 Nov 17. doi: https://doi.org/10.1101/2022.11.17.516844

Efficient Generation of Genome-wide Libraries for Protein–ligand Screens Using Gibson Assembly.

Sternlieb, T., Loock, M., Gao, M. and Cestari, I.

Bio-protocol 2022, 12(22): e4558. DOI: 10.21769/BioProtoc.4558.

The current drug discovery landscape for trypanosomiasis and leishmaniasis: Challenges and strategies to identify drug targets.

Altamura F, Rajesh R, Catta-Preta CMC, Moretti NS, Cestari I.

Drug Dev Res. 2022 Apr;83(2):225-252. doi: 10.1002/ddr.21664. Epub 2020 Apr 6. PMID: 32249457 

Phosphoinositide signaling and regulation in Trypanosoma brucei: Specialized functions in a protozoan pathogen.

Cestari I.

PLoS Pathog. 2020 Jan 2;16(1):e1008167. doi: 10.1371/journal.ppat.1008167. eCollection 2020 Jan.PMID: 31895930 

Identification of Inositol Phosphate or Phosphoinositide Interacting Proteins by Affinity Chromatography Coupled to Western Blot or Mass Spectrometry.

Cestari I.

J Vis Exp. 2019 Jul 26;(149). doi: 10.3791/59865.PMID: 31403622

Nuclear Phosphatidylinositol 5-Phosphatase Is Essential for Allelic Exclusion of Variant Surface Glycoprotein Genes in Trypanosomes.

Cestari I, McLeland-Wieser H, Stuart K. 

Mol Cell Biol. 2019 Jan 16;39(3):e00395-18. doi: 10.1128/MCB.00395-18. PMID: 30420356; PMCID: PMC6336139. Selected postdoctoral work.

Chemogenetic Characterization of Inositol Phosphate Metabolic Pathway Reveals Druggable Enzymes for Targeting Kinetoplastid Parasites.

Cestari I, Haas P, Moretti NS, Schenkman S, Stuart K. 

Cell Chem Biol. 2016 May 19;23(5):608-617. doi: 10.1016/j.chembiol.2016.03.015. Epub 2016 Apr 28.PMID: 27133314. Selected postdoctoral work. 

Inositol phosphate pathway controls transcription of telomeric expression sites in trypanosomes. 

Cestari I, Stuart K.

Proc Natl Acad Sci U S A. 2015 May 26;112(21):E2803-12. doi: 10.1073/pnas.1501206112. Epub 2015 May 11. PMID: 25964327; PMCID: PMC4450425. Selected postdoctoral work.

Publications with collaborators

Helminth-derived metabolites induce tolerogenic functional, metabolic, and transcriptional signatures in dendritic cells that attenuate experimental colitis

Malacco NL, Michi AN, Siciliani E, Madrigal AG, Sternlieb T, Fontes G, King IL, Cestari I, Jardim A, Stevenson MM, Lopes F

bioRxiv 2023.01.26.525718; doi: https://doi.org/10.1101/2023.01.26.525718

Editorial: Cellular immune response and escape mechanisms of intracellular parasites

Dutra PML, Rodrigues LS, Pinheiro RO, Pereira MWF, Cestari I, Da-Silva SAG

Front. Immunol. 2024, Jan 12; Vol 15; doi: https://doi.org/10.3389/fimmu.2024.1362719

Protein acetylation in the critical biological processes in protozoan parasites
Maran SR, Fleck K, Monteiro-Teles NM, Isebe T, Walrad P, Jeffers V, Cestari I, Vasconcelos EJR, Moretti N. 
Trends Parasitol. 2021 May 12; S1471-4922(21)00088-X.  doi: 10.1016/j.pt.2021.04.008.

ATR Kinase Is a Crucial Player Mediating the DNA Damage Response in Trypanosoma brucei.

Marin PA, Obonaga R, Pavani RS, da Silva MS, de Araujo CB, Lima AA, Avila CC, Cestari I, Machado CR, Elias MC.

Front Cell Dev Biol. 2020 Dec 22;8:602956. doi: 10.3389/fcell.2020.602956. eCollection 2020.PMID: 33415107 

Lexis and Grammar of Mitochondrial RNA Processing in Trypanosomes.

Aphasizheva I, Alfonzo J, Carnes J, Cestari I, Cruz-Reyes J, Göringer HU, Hajduk S, LukeÅ¡ J, Madison-Antenucci S, Maslov DA, McDermott SM, Ochsenreiter T, Read LK, Salavati R, Schnaufer A, Schneider A, Simpson L, Stuart K, Yurchenko V, Zhou ZH, Zíková A, Zhang L, Zimmer S, Aphasizhev R.

Trends Parasitol. 2020 Apr;36(4):337-355. doi: 10.1016/j.pt.2020.01.006. Epub 2020 Feb 28.PMID: 32191849 

The phosphoinositide regulatory network in Trypanosoma brucei: Implications for cell-wide regulation in eukaryotes.

Cestari I, Stuart K.

PLoS Negl Trop Dis. 2020 Oct 29;14(10):e0008689. doi: 10.1371/journal.pntd.0008689. eCollection 2020 Oct.PMID: 33119588 

Plasmodium Secretion Induces Hepatocyte Lysosome Exocytosis and Promotes Parasite Entry.

Vijayan K, Cestari I, Mast FD, Glennon EKK, McDermott SM, Kain HS, Brokaw AM, Aitchison JD, Stuart K, Kaushansky A.

iScience. 2019 Nov 22;21:603-611. doi: 10.1016/j.isci.2019.10.054. Epub 2019 Oct 31.PMID: 31731198 

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